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[ccp4bb]: Cross linking
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Another non-computational query !
Does anyone know of examples where cross-linking (preferably
di-sulphide) has been used to probe the relative arrangement of two
(or more) subunits in a (hetero)oligomeric complex (eg by generating
Cys mutants and then checking for cross-linking under oxidising
conditions), but where this data is inconsistent with stuctural
information (ie the relevant residues are too far apart) ??