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RE: [ccp4bb]: Chirality Issue
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> Never paid attention to it before. Isn't there a chirality issue with the
> side chain of Threonine at the Cbeta position???
> Is it always R (rectus) or can it be S also????
The amino acid threonine contains two chiral carbons and thus can
exist in four possible conformations. However, only a single
conformation (2S, 3R) of threonine is incorporated in proteins
by the cellular translation material. The conformation at the
alpha carbon (carbon 2) is the same as that of the other amino
acids in biological proteins, and there is no explanation for
why this enantiomer was selected. Further, there is no explanation
for the choice of conformation at the 3 carbon in threonine.
BR