[ccp4bb]: Re: Thermostability vs Structure

[Jeroen Mesters <jmesters@imb-jena.de>]

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Hello,

my personal impression is that there is no real consensus on this
somewhat difficult topic.

Besides disulfide and salt bridges, also have a look at
less flexible i.e. smaller loops and reduced/smaller hydrophobic patches
on the protein surface. More hydrophobic core i.e. aromatic
clusters helps too.

Jeroen.
--
Jeroen Raymundus Mesters, Ph.D.                           Alias Geronimo
Dept. of Structural Biology and Crystallography,  Institute of Molecular
Biotechnology, P.O.Box 100 813, D-07708 Jena, Germany.
Tel: +49-3641-656063, Fax: +49-3641-656062, E-mail: jmesters@imb-jena.de
http://www.imb-jena.de/www_sbx/home.html
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