RE: [ccp4bb]: map coefficients in Refmac and CNS

["Frank Vondelft" <Frank.Vondelft@syrrx.com>]

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Hi Jorge

> 2) What is the so called phi_calc phase in CNS ? The corresponding PHIC of 
> REFMAC, that is, based solely on the model coordinates?  But, should these
> phases not bias the density towards the model and then explain why I see a 
> better density around my ligand in CNS maps ? 

Did you include your ligand in the refinement?  (Your question seems to imply you did.)  If you want to decide what's in there, you should definitely remove whatever you *thought* was there, and judge by the difference density.

Cheers
phx.