*** For details on how to be removed from this list visit the *** *** CCP4 home page http://www.ccp4.ac.uk *** Hi: I am refining a structure at 2.2 A which appears to have a ligand. The ed surrounding this site cannot be satisfactorily accounted for with only waters. How would one go about improving the ed? The current R=20% with Rfree 26%. rafi