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Re: [ccp4bb]: Off topic: enzyme active sites
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On Monday, February 3, 2003, at 05:03 AM, Aaron Oakley wrote:
> Greetings all,
> I am looking for examples of enzymes that can catalyse UNRELATED
> reactions (unique chemical reactions) using a SINGLE active site, and
> where the catalytic residues are the SAME for both reactions (but
> utilized differently). This does not include, for example,
> esterase/peptideses (where the mechanisms are essentially the same),
> or proteins with different activities located in different active
> sites on the same polypeptide chain.
One example is Leukotriene A4 Hydrolase. It has both a tripeptidase and
epoxide hydrolase activity, both involving a catalytic Zinc ion and
some associated machinery for activating the incident water molecule.
Ian Ollmann, Ph.D.
Vector and Numerics Group