Re: [ccp4bb]: Off topic: enzyme active sites

[Ian Ollmann <iano@apple.com>]

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On Monday, February 3, 2003, at 05:03  AM, Aaron Oakley wrote:

> Greetings all,
>  
> I am looking for examples of enzymes that can catalyse UNRELATED 
> reactions (unique chemical reactions) using a SINGLE active site, and 
> where the catalytic residues are the SAME for both reactions (but 
> utilized differently). This does not include, for example, 
> esterase/peptideses (where the mechanisms are essentially the same), 
> or proteins with different activities located in different active 
> sites on the same polypeptide chain.


One example is Leukotriene A4 Hydrolase. It has both a tripeptidase and 
epoxide hydrolase activity, both involving a catalytic Zinc ion and 
some associated machinery for activating the incident water molecule.

Best Regards,

Ian Ollmann, Ph.D.
Vector and Numerics Group
Software Division
Apple Computer