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[ccp4bb]: orthorhombic twinning

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dear all,
i have a crystal with orthorhombic space group (P212121) with two cell
dimensions lenght very similar, so i think that the crystal is twinned.
So, what can i do now? is there a software to detwin my data also in this
particular case?  There something else that i should try (except to search
for different crystallization conditions?)?  thank you