Serine Proteinases
Bacterial trypsin-like
Hydrogen Bonding Diagram
Blue arrows indicate hydrogen bonding interactions between the enzyme and the inhibitors
General information about bacterial trypsin-like serine proteinases
Structural Comparisons
Overlap of fitted inhibitor structures.
Overlap of fitted protein structures.
The representatives are 1hpg (Glutamic acid-specific protease), 1arb (Achromobacter Protease I), 1alp (Alpha-lytic proteinase), 2sga (Proteinase A) and 3sgb (Proteinase B).
| PDB Code | PDB Info | Protein | Source | E.C. no. | Res./Å. | R-factor | Inhibitor | Covalent | Inhibitor bound in active site | |
| 1HPG | View | Glutamic acid specific protease | Streptomyces griseus | 3.4.21.82 | 1.5 | 18.1 | Boc-Ala-Ala-Pro-Glu | No | View | |
| 1ARB | View | Achromobacter Protease I | Achromobacter lyticus (M497-1) | 3.4.21.50 | 1.2 | 14.9 | None | - | - | |
| 1ARC | View | Achromobacter Protease I | Achromobacter lyticus (M497-1) | 3.4.21.50 | 2.0 | 15.2 | Tosyl-Lys-Chloromethylketone HCl | Yes | View | |
| 2ALP | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 1.7 | 13.1 | None | - | - | |
| 1LPR | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.1 | 13.6 | Methoxysuccinyl-Ala-Ala-Pro-Alanine boronic acid | Yes | View | |
| 1P01 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.0 | 13.8 | Boc-Ala-Pro-Valine boronic acid | Yes | View | |
| 1P02 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.0 | 14.7 | Methoxysuccinyl-Ala-Ala-Pro-Alanine boronic acid | Yes | View | |
| 1P03 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.1 | 14.2 | Methoxysuccinyl-Ala-Ala-Pro-Valine boronic acid | Yes | View | |
| 1P04 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.55 | 13.4 | Methoxysuccinyl-Ala-Ala-Pro-Isoleucine boronic acid | Yes | View | |
| 1P05 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.1 | 13.9 | Methoxysuccinyl-Ala-Ala-Pro-Norleucine boronic acid | Yes | View | |
| 1P06 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.34 | 14.0 | Methoxysuccinyl-Ala-Ala-Pro-Phe boronic acid | Yes | View | |
| 1P08 | View | Alpha-lytic Protease (M192A) | Lysobacter enzymogenes | 3.4.21.12 | 2.25 | 13.9 | Methoxysuccinyl-Ala-Ala-Pro-Phe boronic acid | Yes | View | |
| 1P09 | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.2 | 13.5 | None | - | - | |
| 1P10 | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.25 | 14.4 | Methoxysuccinyl-Ala-Ala-Pro-Val boronic acid | Yes | View | |
| 1P11 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 1.93 | 12.8 | [Phenoxy(Boc-Ala-Pro-(1-amino-2-methylpropyl) phosphinyloxy)-propanoyl]-Ala methyl ester | Yes | View | |
| 1P12 | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 1.90 | 12.4 | [Phenoxy(Boc-Ala-Pro-(1-amino-2-methylpropyl) phosphinyloxy)-propanoyl]-Ala methyl ester | Yes | View | |
| 2P07 | View | Alpha-lytic Protease (M192A) | Lysobacter enzymogenes | 3.4.21.12 | 2.0 | 13.5 | None | - | - | |
| 2LPR | View | Alpha-lytic Protease (M192A) | Lysobacter enzymogenes | 3.4.21.12 | 2.25 | 12.7 | Methoxysuccinyl-Ala-Ala-Pro-Val boronic acid | Yes | View | |
| 3LPR | View | Alpha-lytic Protease (M192A) | Lysobacter enzymogenes | 3.4.21.12 | 2.15 | 13.8 | Methoxysuccinyl-Ala-Ala-Pro-Norleucine boronic acid | Yes | View | |
| 4LPR | View | Alpha-lytic Protease (M192A) | Lysobacter enzymogenes | 3.4.21.12 | 2.10 | 13.6 | Methoxysuccinyl-Ala-Ala-Pro-Leu boronic acid | Yes | View | |
| 5LPR | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.13 | 13.4 | Methoxysuccinyl-Ala-Ala-Pro-Ala boronic acid | Yes | View | |
| 6LPR | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.10 | 13.2 | Methoxysuccinyl-Ala-Ala-Pro-Norleucine boronic acid | Yes | View | |
| 7LPR | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.05 | 13.6 | Methoxysuccinyl-Ala-Ala-Pro-Leu boronic acid | Yes | View | |
| 8LPR | View | Alpha-lytic Protease (M213A) | Lysobacter enzymogenes | 3.4.21.12 | 2.25 | 13.2 | Methoxysuccinyl-Ala-Ala-Pro-Phe boronic acid | Yes | View | |
| 9LPR | View | Alpha-lytic Protease | Lysobacter enzymogenes | 3.4.21.12 | 2.20 | 12.9 | Methoxysuccinyl-Ala-Ala-Pro-Leu boronic acid | Yes | View | |
| 1SGC | View | Proteinase A | Streptomyces griseus | Not Assigned | 1.8 | 12.3 | Chymostatin | Yes | View | |
| 2SGA | View | Proteinase A | Streptomyces griseus | Not Assigned | 1.5 | 12.6 | None | - | - | |
| 3SGA | View | Proteinase A | Streptomyces griseus | Not Assigned | 1.8 | 12.0 | Ace-Pro-Ala-Pro-Phe-aldehyde | Yes | View | |
| 4SGA | View | Proteinase A | Streptomyces griseus | Not Assigned | 1.8 | 11.6 | Ace-Pro-Ala-Pro-Phe | No | View | |
| 5SGA | View | Proteinase A | Streptomyces griseus | Not Assigned | 1.8 | 11.6 | Ace-Pro-Ala-Pro-Tyr | No | View | |
| 3SGB | View | Proteinase B | Streptomyces griseus | Not Assigned | 1.8 | 14.0 | Turkey Ovomucoid Inhibitor (3rd domain) | No | View | |
| 4SGB | View | Proteinase B | Streptomyces griseus | Not Assigned | 2.1 | 14.2 | Potato Inhibitor PCI-1 | No | View |