Metallo Proteinases
Thermolysin-like
Hydrogen Bonding Diagram
Blue arrows indicate hydrogen bonding interactions between the enzyme and the inhibitors
General information about thermolysin-like metalloproteinases
Structural Comparisons
Overlap of fitted inhibitor structures
Overlap of fitted protein structures.
The representatives are 1ezm (Elastase), 1npc (Neutral Protease) and 1lnf (Thermolysin).
| PDB Code | PDB Info | Protein | Source | E.C. no. | Res./Å | R-factor | Inhibitor | Covalent | Inhibitor bound in active site | |
| 1EZM | View | Elastase | Pseudomonas aeruginosa | 3.4.24.26 | 1.5 | 17.6 | None | - | - | |
| 1NPC | View | Neutral Protease | Bacillus Cereus (DSM 3101) | 3.4.24.27 | 2.0 | 17.5 | None | - | - | |
| 1HYT | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 15.7 | Benzylsuccinic Acid | No | View | |
| 1LNA | View | Thermolysin (Cobalt replaces zinc) | Bacillus thermoproteolyticus | 3.4.24.27 | 1.9 | 15.0 | Val-Lys Dipeptide | No | View | |
| 1LNB | View | Thermolysin (Iron replaces zinc) | Bacillus thermoproteolyticus | 3.4.24.27 | 1.8 | 15.2 | Val-Lys Dipeptide | No | View | |
| 1LNC | View | Thermolysin (Manganese replaces zinc) | Bacillus thermoproteolyticus | 3.4.24.27 | 1.8 | 15.2 | Val-Lys Dipeptide | No | View | |
| 1LND | View | Thermolysin (Complexed with zinc) | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 15.7 | Val-Lys Dipeptide | No | View | |
| 1LNE | View | Thermolysin (Cadmium replaces zinc) | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 16.0 | Val-Lys Dipeptide | No | View | |
| 1LNF | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 15.2 | Val-Lys Dipeptide | No | View | |
| 1THL | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 16.2 | Glutaramide derivative | No | View | |
| 1TLP | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 2.3 | 17.4 | Phosphoramidon | No | View | |
| 1TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.9 | 17.1 | (1-Carboxy-3-Phenylpropyl)-Leu-Trp | No | View | |
| 2TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.6 | 17.9 | N-Phosphoryl-L-Leucinamide | No | View | |
| 3TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 17.3 | Val-Trp | No | View | |
| 4TLN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 2.3 | 16.9 | L-Leu-Hydroxylamine | No | View | |
| 4TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.7 | 17.0 | Carbobenzoxy-Modified Phe-Leu-Ala | No | View | |
| 5TLN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 2.3 | 17.9 | HONH-Benzylmalonyl-L-Alanylglycine-P-Nitroanilide | No | View | |
| 5TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.6 | 17.7 | Carbobenzoxy-Modified Gly-Leu-Leu | No | View | |
| 6TMN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.6 | 17.1 | Carbobenzoxy-Modified Gly-Modified Leu-Leu | No | View | |
| 7TLN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 2.3 | 17.0 | CH2CO(N-OH)Leu-OCH3 | No | View | |
| 8TLN | View | Thermolysin | Bacillus thermoproteolyticus | 3.4.24.27 | 1.6 | 16.5 | Val-Lys dipeptide | No | View |