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FWD: Refinement workshop in York in December 1998
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From: Keith Wilson <keith@yorvic.york.ac.uk>
Subject: Refinement workshop in York in December 1998
EC and CCP4 Workshop
Refinement of Macromolecular structures
We are organising a workshop from December 14 to 20th 1998 in York on
problems in refinement and validation of macromolecular structure. The
workshop aims to provide a sound training in these techniques and is part
of our aim to promote good practice.
The travel, accomodation and course fees for European students will be
paid by the EC contract CT 94-0690 (Development of Advanced Methods:
Please note: This is a 1994 contract, only covering the following EU
states: Denmark, France, Germany, Greece, Italy, Netherlands, Portugal,
Spain) and by CCP4 for those working in the UK.
The workshop will combine lectures and practicals. The course is aimed at
PhD students and post-docs new to crystallographic refinement. Numbers are
limited to 20 students. Supervisors are asked to nominate one student per
laboratory. Amongst the topics to be considered will be
1 Principles of refinement
2 Parameterisation of the model
… When to use Rigid body
… Models generated using torsion angles
… Group temperature factors
… Anisotropic temperature factors
3 Residuals to minimise
… Maximum likelihood
… Least squares
… How to incorporate restraints or constraints
4 How to improve the model
5 Validation techniques and PDB submission
Speakers/tutors will include
Garib Murshudov York REFMAC, maximum likelihood
Isobel Uson Göttingen SHELX, least-squares
Paul Adams Boston CNS, torsion angle refinement
Anastasis Perrakis Grenoble Automated refinement
Eleanor Dodson York General topics
Randy Read Cambridge CNS, maximum likelihood
Details of the program will shortly appear on the WWW:
(http://www.yorvic.york.ac.uk/~refwork
Send applications with short c.v. to Dr E.J.Dodson, University of York,
Heslington,York YO1 5DD,UK from whom further details may be obtained. (
Tel: 44 1904 432520, Email E.Dodson@yorvic.york.ac.uk).
Students should include a letter of support from their supervisor.
*********************************************************
* Keith S Wilson *
* Protein Structure Group *
* Department of Chemistry *
* University of York *
* Heslington *
* York YO1 5DD *
* UK *
* Tel 00 44 1904 432519 Secretary *
* 432575 Direct *
* Fax 410519 *
* Email keith@yorvic.york.ac.uk *
*********************************************************