[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
[ccp4bb]: dipeptide derivative for phasing
*** For details on how to be removed from this list visit the ***
*** CCP4 home page http://www.ccp4.ac.uk ***
Dear all
I'd like to do heavy-atom derivatives of my crystals in order to do
isomorphous replacement. Since I cocrystalize my protein (a cyclophilin)
with a dipeptide (ala-pro), a possibility would be a dipeptide
derivative. Is this feasible? Does somebody know a suitable heavy-atom
compound; the proline is essential, the alanine can be exchanged against
another small aminoacid (e.g. ser, gly, val).
Thanks
Andreas