[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
Re: [ccp4bb]: questions on dimers in crystal packing
*** For details on how to be removed from this list visit the ***
*** CCP4 home page http://www.ccp4.ac.uk ***
Actually, you can form different dimers depending on your crystallographic symmetry. To
decide which dimer is functional in solution is a different issue.
I have seen cases where Small-Angle X-ray Scattering (SAXS) was able to determine which
dimer was functional in solution, what was not clear from the crystal only.
PS: A good site for SAXS is
Rongjin Guan wrote:
> Sorry this is not a ccp4 question.
> Can anybody give some hints on the following questions?
> 1. Can one molecule form more than 1 kind of dimers
> in different crystallization conditions?
> 2. If the answer is "yes", is there any possibilities
> that there is a dynamic equilibruim between them, and
> what we see in the crystal structure is the main
> dimeric form or the favorite dimer form?
> 3. what are the main factors controling the dimer formation?
> 4. Can the dimer formed in crystals reflect the situation in
> if it is known to function as dimers biologically?
> any hints and clues will be greatly appreciated.
> Rongjin Guan, Ph.D.
> Center for Advanced Research in Biotechnology
> 9600 Gudelsky Drive
> Rockville MD, 20850
> Tel: 301-738-6210
> Fax: 301-738-6255