FBLD 2008 Scientific Advisory Board

Harren Jhoti

Harren Jhoti is the Founder, CSO & EVP of Astex Therapeutics, a leading fragment-based drug discovery company based in the UK. Astex has discovered two drug candidates AT7519 & AT9283 using its fragment-based discovery platform, Pyramid, which are in early clinical trials in cancer patients. A further three drug candidates (AT9311, AT13387, AT13148) are in formal preclinical development and were also discovered using Pyramid. Dr. Jhoti is a co-author of several publications describing fragment-based drug discovery including the key paper describing Pyramid (Hartshorn et al, 2005 J. Med Chem) which was the second most cited J. Med Chem paper in 2005. Dr. Jhoti was also featured in TIME magazine as a technology pioneer in 2005.