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[ccp4bb]: Co-crystallisation with hydrophobic ligands



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Hi,

Im wondering if anyone has any clever strategies for co-crystallising
complexes with very hydrophobic ligands.  The ligands I am using are
insoluble at concentrations upwards of 100-200ÁM in buffer and are
soluble in DMSO only up to 50mM.

Many thanks for your time,

Leo James