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[ccp4bb]: CCP4 2001 Study Weekend

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            Molecular Replacement 
              and its Relatives

           A meeting organised by 
   the Collaborative Computational Project in
     Macromolecular Crystallography (CCP4)
          and Daresbury Laboratory

              5-6th January 2001
            The University of York

Molecular replacement is one of the most productive tools for the solution
of crystal structures from x-ray data. This study weekend will bring
together the latest developments in traditional molecular replacement
along with new applications of related methods to different problems in
x-ray crystallography.

Traditional molecular replacement calculations are being improved to allow
the solution of structures with poorer data or less homologous models
through the use of such techniques as likelihood targets and known
symmetry elements within the crystal. New optimisation procedures, such as
the genetic algorithm, are also being employed.

At the same time this has allowed the use of exotic search models, such as
EM or solution scattering density, NMR models, and ensemble structures.
Analysis of the protein database may also provide search models with
suitable folds even in cases where there is no known relationship to an
existing structure. 

Finally, ideas derived from molecular replacement techniques are being
used to solve other problems, in particular the problem of identifying
structural features in low quality electron density maps. 

Invited speakers include:
P Evans (MRC Cambridge)
M G Rossmann (Purdue, USA)
J Navaza (France)
R Read (Cambridge)
L Tong (New York, USA)
R Grosse-Kunstleve (Berkeley, USA)
Quan Hao (DeMontfort)
J M Thornton (London)
Yu Wai Chen (MRC Cambridge)
C R Kissinger (San Diego, USA)

How to apply:
For a web registration form and more details visit the CCP4 WWW homepage
at http://www.dl.ac.uk/CCP/CCP4/main.html and follow the courses link.

Scientific Organisers: Jim Naismith (St Andrews) and Kevin Cowtan (York)
Organisers: Alun Ashton, David Brown and Pat Broadhurst

Further enquiries can be made to ccp4conf@dl.ac.uk (Tel: +44 (0)1925
603528; Fax: +44 (0)1925 603124; or to David Brown, Daresbury Laboratory,
Daresbury, Warrington, WA4 4AD, UK).

The closing date for application is 15th November 2000. Applications must
be received by this date.