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[ccp4bb]: Protein crystallography postdoctoral fellowship at Abbott Bioresearch Center, Inc.
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Post-Doctoral Fellow, Protein Crystallography (Position Code: T 351)
A new postdoctoral fellowship position is available in the structural biology
group at Abbott Bioresearch Center in Worcester, MA, located 45 minutes west of
Boston. Abbott Bioresearch Center, a division of Abbott Laboratories, has
vibrant research programs on traditional, low molecular weight pharmaceuticals
and fully-human, monoclonal antibody pharma-ceuticals in the immunology and
oncology therapeutic areas. The structural biology group is fully-integrated
into the drug design process at ABC, and exciting opportunities for both
scientific and career development exist.
Four areas of investigation are open to the successful candidate: 1. Structure
determination of protein kinases involved in cellular signaling pathways,
including both therapeutic targets and counterscreen enzymes. 2. Structure
determination of therapeutic human monoclonal antibodies, the mAb ligands, and
the mAb/ligand complexes. 3. Structure-based optimization of dual-specific mAbs
and conversion of mouse to human mAb with retention of binding characteristics.
4. Design and implementation of rapid protein expression and purification
methods to produce proteins for crystallization. Requirements: Ph.D. in Protein
Crystallography, Chemistry, Biochemistry, Physics, or Molecular Biology.
Demonstrated hands-on expertise in the production and characterization of
protein crystals, collection and processing of x-ray diffraction data,
determination and interpretation of protein crystal structures, and presentation
of results. Experience in simple molecular biology techniques, recombinant
protein expression, protein purification. Synchrotron data collection and MAD
phasing. Willingness to participate in the implementation of robotic
technologies. Travel several times a year to synchrotron radiation facilities
for data collection is required. Strong analytical and communication skills are
The protein crystallography laboratory at Abbott Bioresearch Center is equipped
with a Nonius FR571 x-ray generator, MarResearch CCD and MAR345 image plate
detectors, Osmic optics, and Oxford Cryostream cryogenics. We also have routine
access to the IMCA-CAT beamlines at the Advanced Photon Source, Argonne National
Laboratory. Ample computational resources are available, and the structural
biology group at ABC is committed, along with our sister group at Abbott Park,
IL, to the automation of the routine crystallographic tasks using
state-of-the-art robotic systems.
Applicants should submit their curriculum vitae, listing names and contact
information for three references, by e-mail to email@example.com (MS
Word, PDF, or plain text, please), ensuring that the Position Code "T 351" and
"David Borhani" are prominent in the Subject line.
Group Leader, Biochemistry
Abbott Bioresearch Center, Inc.
100 Research Drive
Worcester, MA 01605 USA