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[ccp4bb]: Protein crystallography postdoctoral fellowship at Abbott Bioresearch Center, Inc.

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Post-Doctoral Fellow,  Protein Crystallography (Position Code: T 351)

A new postdoctoral fellowship position is available in the structural biology
group at Abbott Bioresearch Center in Worcester, MA, located 45 minutes west of
Boston. Abbott Bioresearch Center, a division of Abbott Laboratories, has
vibrant research programs on traditional, low molecular weight pharmaceuticals
and fully-human, monoclonal antibody pharma-ceuticals in the immunology and
oncology therapeutic areas. The structural biology group is fully-integrated
into the drug design process at ABC, and exciting opportunities for both
scientific and career development exist.

Four  areas  of investigation are open to the successful candidate: 1. Structure
determination  of  protein  kinases  involved  in  cellular  signaling pathways,
including  both  therapeutic  targets  and  counterscreen  enzymes. 2. Structure
determination  of  therapeutic human monoclonal antibodies, the mAb ligands, and
the  mAb/ligand complexes. 3. Structure-based optimization of dual-specific mAbs
and  conversion of mouse to human mAb with retention of binding characteristics.
4.  Design  and  implementation  of  rapid  protein  expression and purification
methods  to produce proteins for crystallization. Requirements: Ph.D. in Protein
Crystallography,   Chemistry,   Biochemistry,  Physics,  or  Molecular  Biology.
Demonstrated  hands-on  expertise  in  the  production  and  characterization of
protein   crystals,   collection  and  processing  of  x-ray  diffraction  data,
determination and interpretation of protein crystal structures, and presentation
of  results.  Experience  in  simple  molecular  biology techniques, recombinant
protein  expression,  protein  purification. Synchrotron data collection and MAD
phasing.   Willingness   to   participate   in  the  implementation  of  robotic
technologies.  Travel  several  times a year to synchrotron radiation facilities
for  data collection is required. Strong analytical and communication skills are
a must.

The  protein crystallography laboratory at Abbott Bioresearch Center is equipped
with  a  Nonius  FR571  x-ray  generator, MarResearch CCD and MAR345 image plate
detectors,  Osmic optics, and Oxford Cryostream cryogenics. We also have routine
access to the IMCA-CAT beamlines at the Advanced Photon Source, Argonne National
Laboratory.  Ample  computational  resources  are  available, and the structural
biology  group  at ABC is committed, along with our sister group at Abbott Park,
IL,   to   the   automation   of   the   routine  crystallographic  tasks  using
state-of-the-art robotic systems.

Applicants  should  submit  their  curriculum  vitae,  listing names and contact
information  for  three  references,  by  e-mail to worcesterjobs@abbott.com (MS
Word,  PDF,  or plain text, please), ensuring that the Position Code "T 351" and
"David Borhani" are prominent in the Subject line.

David Borhani
Group Leader, Biochemistry
Abbott Bioresearch Center, Inc.
100 Research Drive
Worcester, MA 01605 USA