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[ccp4bb]: Biochemistry/Protein crystallography Senior Scientist at Abbott Bioresearch Center, Inc.
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Senior Scientist - Biochemistry and/or Protein Crystallography (Position Code:
A new senior scientist position is available in the structural biology group at
Abbott Bioresearch Center in Worcester, MA, located 45 minutes west of Boston.
Abbott Bioresearch Center, a division of Abbott Laboratories, has vibrant
research programs on traditional, low molecular weight pharmaceuticals and
fully-human, monoclonal antibody pharmaceuticals in the immunology and oncology
therapeutic areas. The structural biology group is fully-integrated into the
drug design process at ABC, and exciting opportunities for both scientific and
career development exist.
The successful candidate will conduct protein purification and characterization
(including enzymatic and biophysical assays) in support of therapeutic target
characterization, inhibitor testing, and structural biology efforts on drug
discovery programs. Responsibilities include making significant intellectual
contributions to project design and goals and, for protein crystallography
applicants, performing hands-on experiments in all stages of a protein crystal
structure determination. Requirements: Ph.D. in Biochemistry or Enzymology,
Chemistry, Molecular Biology, or equivalent, as well as several years of
postdoctoral experience are required. Demonstrated success in production of
biologically-active recombinant proteins. At least three years of hands-on
laboratory experience in the development and implementation of protocols for
protein purification, protein characterization, enzymatic, and other biophysical
techniques (e.g. fluorescence, CD) is required. Experience in recombinant
protein expression and refolding of insoluble proteins. Experience with
fermentation (E. coli, yeast, baculovirus) is a plus. Experience in a
pharmaceutical or biotechnology environment is especially helpful.
Crystallography applicants must have a demonstrated ability to carry out all
stages of a protein crystal structure determination and to interpret the
results, complete familiarity with diverse crystallographic computing
methodologies (software and operating systems), and experience with minor
equipment maintenance/repair and synchrotron radiation. Travel several times a
year to synchrotron radiation facilities for data collection is required. For
all applicants, strong analytical and communication skills are a must. Beyond
these core competencies, the successful candidate should have broad experience
in one or more of the disciplines that interface with the structural biology
group, such as organic or medicinal chemistry, molecular biology, protein
purification and characterization, enzymology, or pharmacology. This experience,
coupled with outstanding communication and interpersonal skills, will ensure
effective interactions with interdisciplinary drug design teams.
The protein crystallography laboratory at Abbott Bioresearch Center is equipped
with a Nonius FR571 x-ray generator, MarResearch CCD and MAR345 image plate
detectors, Osmic optics, and Oxford Cryostream cryogenics. We also have routine
access to the IMCA-CAT beamlines at the Advanced Photon Source, Argonne National
Laboratory. Ample computational resources are available, and the structural
biology group at ABC is committed, along with our sister group at Abbott Park,
IL, to the automation of the routine crystallographic tasks using
state-of-the-art robotic systems.
Applicants should submit their curriculum vitae, listing names and contact
information for three references, by e-mail to firstname.lastname@example.org (MS
Word, PDF, or plain text, please), ensuring that the Position Code "Biochem 02"
and "David Borhani" are prominent in the Subject line.
Group Leader, Biochemistry
Abbott Bioresearch Center, Inc.
100 Research Drive
Worcester, MA 01605 USA