Re: [ccp4bb]: unusually high solvent content

["Eleanor J. Dodson" <ccp4@ysbl.york.ac.uk>]

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JoaoMDias wrote:
> 
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> Dear All,
> 
> According to Matthews, (Mathews, B. W. (1968). J. Mol. Biol. 33,
> 491-497.), the Matthew's coefficient of protein crystals is usually
> comprehended between 1.7-3.5 A3/Da.
> 
> Are there many proteins with a much higher solvent content that the
> Matthews limits?
> 
> Do you have experience with protein crystals with high solvent contents?
> 
> Could you point me some references to published works, or reviews about
> protein crystal structures with unusual VM (above 70%)?
> 
> Thanks in advance and Merry Christmas,
> Joao Miguel


 Well - of course they exist; you can get crystals with 80% +  solvent..
Often shells where there is a large amount of disorder within a capsid
say..

 Dont know of any review though.
It is great for phasing IF you can get started! Density modification
works a treat..
  Eleanor

But