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[ccp4bb]: unusually high solvent content

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Dear All,

According to Matthews, (Mathews, B. W. (1968). J. Mol. Biol. 33,
491-497.), the Matthew's coefficient of protein crystals is usually
comprehended between 1.7-3.5 A3/Da.

Are there many proteins with a much higher solvent content that the
Matthews limits?

Do you have experience with protein crystals with high solvent contents?

Could you point me some references to published works, or reviews about
protein crystal structures with unusual VM (above 70%)?

Thanks in advance and Merry Christmas,
Joao Miguel