[ccp4bb]: REFMAC5 maximum likelihood refinement

["Wolfram Tempel" <tempel@sgx3.bmb.uga.edu>]

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Hi all,
under which circumstances would maximum likelihood target refinement in 
REFMAC5 produce a dramatic INCREASE in R (from 0.187 to 0.208) and Rfree 
(from 0.232 to 0.257) with 1.8A data? This was not accompanied by 
improved geometry (reduced RMSs). Any idea where I should start looking 
for the underlying problem?
Thank you.
Wolfram Tempel
U. of Georgia