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Re: [ccp4bb]: Examples of pH affecting ligand conformation wanted
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Gerard \"DVD\" Kleywegt wrote:
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> Does anybody know of any published example of a case where
> pH affects the observed conformation of a cocrystallised
> ligand ? I.e., the same ligand in complex with the same
> protein assumes different conformations at different pH
> levels.
>
> Replies directly to me please, not to the mailing list(s).
>
> Thanks !!
>
> --Gerard
>
> ******************************************************************
> Gerard J. Kleywegt
> [Research Fellow of the Royal Swedish Academy of Sciences]
> Dept. of Cell & Molecular Biology University of Uppsala
> Biomedical Centre Box 596
> SE-751 24 Uppsala SWEDEN
>
> http://xray.bmc.uu.se/gerard/ mailto:gerard@xray.bmc.uu.se
> ******************************************************************
> The opinions in this message are fictional. Any similarity
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have a look at this one:
pH-dependent binding modes observed in trypsin crystals: Lessons for
structure-based drug design
Stubbs MT, Reyda S, Dullweber F, Moller M, Klebe G, Dorsch D, Mederski
WWKR, Wurziger H
CHEMBIOCHEM
3 (2-3): 246-249 MAR 1 2002
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