The Karle-Hauptman matrix of a set of unitary structure factors can be defined as follows,
or,
where , and conventionally .
Consider the product of two Karle-Hauptman matrices of and , where .
If enough reflections are included in the Karle-Hauptman determinant, the summation over becomes the Fourier inversion formula for , thus:
If , then:
i.e. is the inverse of . Thus, if enough terms are included, the Karle-Hauptman matrix associated with the inverse of an electron density function is the inverse of the Karle-Hauptman matrix associated with the electron density function itself.