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["S. Parthasarathy" <spartha@sanketh.mbu.iisc.ernet.in>]

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	Dear all,

	I am in the process of refinig a TIM-2PG (2-phosphoglycerate)
	at high resolution.

	One expect only the D- isomer to bound to the active site.

	I would like calculate the Chiral volume of this ligand to use
	as restraint in SHELX-97 refinement.

	(a) could any one help me by suggesting a program which can do 
	the needfull ?
	
	(b) what if one does not use this as restraint in a case where 
	the resolution of the data is near atomic resolution ?
	
	Looking forward to your replies.

	Thanks a lot.

	S.Parthasarathy.
	Molecular Biophysics Unit
	Indian Insititute of Science
	Bangalore 560 012 India