*** For details on how to be removed from this list visit the *** *** CCP4 home page http://www.ccp4.ac.uk *** Dear all: May be this is an oldie but.. I refined my structure using Refmac5 and CNS using the same set of Rtest reflections. Always, Refmac5 gave a lower R-factor compared to CNS using max likelyhood refinement. Has anybody else noticed this? Why would this occur? Thanks Rafi