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Re: [ccp4bb]: Re: (fwd)
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On Monday, March 18, 2002, at 07:00 PM, marius wrote:
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>> Any ideas out there how fast the conformations of side chain
>> double conformations might interchange ? More specifically:
>> How often (per second) hops the side chain
>> from conformation one into the other or back.
>> Please, refer to literature.
>
> You start by making the assumption that the disorder is dynamic, ie
> they do hop a
> few times per second, while the disorder might well be (and is in many
> cases)
> static.
>
> Tried a PUBMED search first ?
>
>
If I remember correctly, there is a discussion of this topic in the
book
Proteins: A Theoretical Perspective of Dynamics, Structure and
Thermodynamics
By Charles L. Brooks,Martin Karplus,B. Montgomery.
Specifically, it was about the timescale for PHE sidechains to flip.
Richard Gillilan
MacCHESS
Cornell University