Re: [ccp4bb]: R-sym I/sigI etc...

[Jim Pflugrath <jwp@RigakuMSC.com>]

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Can you prove that the refined model is "better" with the additional
data and resolution?  That is, sure "everything looks fine", but is it
meaningful?  If you cut off at 1.5 Angstrom resolution, does anything get
worse?  Can you prove that it gets worse?  If there is no difference
cutting off at a lower resolution, what does that say about the higher
resolution data?

Personally, I'd give up and agree to the referee's lower resolution
request.  I'm not quite sure what you mean by cutting your redundancy
though.

Let the debate rage on ...

Jim

> I sent a crystallization manuscript with
> R-sym in final shell 60.7 Redundancy 8.1 I/sigI 0.9 9all in the final
> shell).
>
> Acta D refused to publish it (a crystallization manuscript) unless I cut
> my resolution or my redundancy  to get better R-sym at the outermost shell
> or cut I/sig I at 1.5..
>
> The catch is as you collect data to this redundancy the data does get
> weaker and I/sigI gets poorer. I personally think this fine as we have
> solved the structure refined etc.. etc.. and everything looks fine.
>
> So, do I give up to referees request and publish with lower resolution
> cutoff / lower redundancy cutoff etc.. of do I fight or do I just not
> publish the crystallization paper (which is what I am now inclined to
> do)..
>
> I thought I would poll the web before I decide....
>
> Thanks.
>
> Rams.