Re: [ccp4bb]: R-sym I/sigI etc...

[Roberto Steiner <steiner@ysbl.york.ac.uk>]

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Maybe naive but if you have refined your structure and in your outermost shell 
you have R factors lower that 59% I would say there is a non random 
contribution in that shell and therefore no need to cut.

Roberto 

> Hello All,
>
> I thought this was a settled issue.  That R-syms and mean I/sigI's are a
> non -ussue and that the best stratety is to include all information.
>
> I sent a crystallization manuscript with
> R-sym in final shell 60.7 Redundancy 8.1 I/sigI 0.9 9all in the final
> shell).
>
> Acta D refused to publish it (a crystallization manuscript) unless I cut
> my resolution or my redundancy  to get better R-sym at the outermost shell
> or cut I/sig I at 1.5..
>
> The catch is as you collect data to this redundancy the data does get
> weaker and I/sigI gets poorer. I personally think this fine as we have
> solved the structure refined etc.. etc.. and everything looks fine.
>
> So, do I give up to referees request and publish with lower resolution
> cutoff / lower redundancy cutoff etc.. of do I fight or do I just not
> publish the crystallization paper (which is what I am now inclined to
> do)..
>
> I thought I would poll the web before I decide....
>
> Thanks.
>
> Rams.



-- 
Roberto A. Steiner
York Structural Biology Lab, Department of Chemistry
University of York, Heslington, York, YO10 5DD, U.K.
Tel:  (+44) 1904 434531
Fax: (+44) 1904 410519