Re: [ccp4bb]: Refmac vs. cns

["Eleanor J. Dodson" <ccp4@ysbl.york.ac.uk>]

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Jianghai Zhu wrote:
> 
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> Hi,
> 
> I am very interested in this comparison too. Can anybody give me some
> details about the comparison between Refmac5 and CNS? I have never use
> Refmac5 before. Can refmac5 do simulated annealing?
> 
> Thanks.
> 
> ================================
> Jianghai Zhu
> Biochemistry & Molecular Biology
> B203, Lilly Hall
> Purdue University
> Tel: 765-4949247 (O)
>       765-4630228 (H)
> ================================


 Heres a fire storm brewing..
 Can some-one comment on how valuable simulated annealing is at various
resolutions?

 In examples at better than 2.5A we usually seem to finish up doing just
about the same amount of rebuilding as you do after a ML run. 

 Eleanor