Additional Information

FBLD 2009


FBLD 2010 Agenda

Presentations available for download are linked from this page, any talks not linked are unavailable.
Please contact FBLD 2010 Administrator for password details.

Sunday, 10th October, Noon - Registration opens

13:00 - 14:30CCG Workshop "Free MOE Workshop"
14:30 - 15:30CCG + BioSolveIT "Synergies for FBLD"
15.30 - 17:00BioSolveIT Workshop "Fragment-Based Ligand Design in Teams"
17:30 - 19:00Mixer with food and drink

Monday 11th October:

Fragment Libraries and Chemical Space
(Andrew Leach & Mike Hann, GlaxoSmithKline, co-chairs)

8:00 - 8:45   Plenary Introduction: "Current Perspectives in Fragment-Based Discovery"
Rod Hubbard, Vernalis & University of York
8:45 - 9:25Enumeration, Mapping and Scoring of Chemical Space”,
Jean-Louis Reymond, University of Berne
9:25 - 9:55From Druggability, to Ligand Efficiency, to the Universe of Heterocyclic Rings”,
Colin Groom, Cambridge Crystallographic Data Centre
9:55 - 10:25Coffee & Tea
10:25 - 10:55Design and Application of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine”,
Anna Vulpetti, Novartis
10:55 - 11:25Shape Diversity in Fragment Library Design: Theory and Practice”,
Ken Brameld, Roche
11:25 - 11:55"Fragment Based Druggability Screening to Predict Lead Discovery Success",
Fredrik Edfeldt, AstraZeneca R&D
11:55 - 12:25Three - Four 10 minute poster/vendor talks to be selected in August 2010
12:30 - 13:30Lunch, Posters & Vendors

Biophysics A: Hit Identification
(Don Huddler. GlaxoSmithKline, Chair)

13:30 - 14:10“NMR and Computational Approaches to Fragment Hit ID”
Maurizio Pellecchia, Burnham Institute for Medical Research
14:10 - 14:40Ligand-Observed NMR Fragment Screening”,
Ben Davis, Vernalis
14:40 - 15:10Fragment Library Screening with SPR”,
Tony Giannetti, Genentech
15:10 - 15:40Automated SPR Data Processing and Sensogram Classification”,
Constantine Kreatsoulas, Merck
15:40 - 16:10Coffee & Tea
16:10 - 16:40Biophysical Ligand Screening of Soluble and Membrane-Bound Targets”,
Gregg Siegal, ZoBio & Universiteit Leiden
16:40 - 17:10"Small Molecule Fragment Screening with Biolayer Interferometry on the ForteBio Octet Red Instruments",
Charles A. Wartchow, Hoffman La Roche
18:00 - Food, Drink, Posters & Vendors

Tuesday 12th October:

Biophysics B: Screening and Characterization Technologies
(Tony Giannetti, Genentech, Chair)

8:30 - 9:15Overview of Biophysics for Fragment Discovery and Characterization”,
Glynn Williams, Astex Therapeutics
9:15 - 9:45Fragment Screening against Membrane Receptors using SPR - Seriously?”,
Rebecca Rich, University of Utah
9:45 - 10:15“Comparison of plate-based biophysical binding assay methods for fragment library screening”,
Kartik Narayan, Merck
10:15 - 10:45 Coffee & Tea
10:45 - 11:15Predicting success from X-ray Cystallographic Screening of Fragments”,
Doug Davies, Emerald BioStructures
11:15 - 11:45“Culling Through Fragment Hits with Biophysical Approaches”,
Bill Metzler, Bristol-Myers Squibb
11:45 - 12:15"Fragment-based screening for inhibitors of PDE4A using enthalpy arrays and X-ray crystallography",
Michael Recht, Palo Alto Research Centre
12:15 - 13:45Lunch, Posters & Exhibitors

Chemistry Follow-up Strategies
(Dan Erlanson, Carmot Therapeutics, Chair)

13:30 - 14:00From Weak NMR-Detected Fragment Hits to First-in-class Recommendation Candidates for BACE-1”,
Dan Wyss, Merck
14:00 - 14:30"Ups and downs of structurally un-enabled fragment optimization",
Adam Renslo, University of California, San Francisco
14:30 - 15:00Targeting Protein-Protein Interactions via Kinetic Target-Guided Synthesis“,
Roman Manetsch, University of South Florida
15:00 - 15:30Coffee & Tea
15:30 - 16:00Shortening the Time to a Successful Fragment HTL Campaign”,
Sandy Farmer, Boehringer Ingelheim Pharmaceuticals, Inc
16:00 - 16:30"Discovery of new high-affinity PDE10 inhibitors using fragment based lead generation and knowledge-based design",
Jeffrey S. Albert, AstraZeneca
16:30 - 16:50"Novel PDK1 Inhibitors Discovered through FBLD",
M. Catherine Johnson, Pfizer
16:50 - 17:10"FBLD: A PDK1 Case Study",
Jeffrey M. Axten, GlaxoSmithKline
18:00 -Conference Banquet

Wednesday 13th:

Success Stories and Chemical Biology
(Rod Hubbard, Vernalis & The University of York, Chair)

8:30 - 9:10“Fragment-Based Ligand Discovery : New Opportunities with Well-Known Targets”,
Wolfgang Jahnke, Novartis
9:10 - 9:50“Targeting the Intractable”,
Chaohong Sun, Abbott Labs
9:50 - 10:30“Beyond Growing and Linking: Impact of Fragments on the Discovery of Kinase Inhibitors”,
Andreas Kuglstatter, Roche
10:30 - 11:00Coffee & Tea
11:00 - 11:30"Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFr)",
Gordon Saxty, Astex Therapeutics
11:30 - 12:15“Fragments - a Story That Will Run and Run”.
Chris Abell, University of Cambridge
12:30 -Close of Conference

Click to download Conference Flyer (PDF) or Conference Agenda (PDF).

Last Updated: May 13th, 2010

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